Cell Biology, Cell Morphology and Cytology (15 ECTS)

Learning outcomes

Students explain the structures and functions of cells, adhesion of cells to their surroundings, intercellular communication, events relating to the cell life cycle and the properties of a cancer cell.
Students explain the formation, mobility, functions and tests of blood cells and their manifestations in different bodily fluids. They describe sampling of aspirates and preparation of bone marrow smears. Students
-use microscopes and recognise and sort blood, urine and aspirate cells and particles to a high quality standard using different methods and describe related anomalous findings
- recognise the significance of cytological diagnostics of diseases and to treatment of patients
-different cell types based on histological cell morphology and can distinguish between normal and atypical cells in key sample types according to the criteria of malignancy
-justify the significance of clinical cytology tests to treating patients, diagnosing diseases and monitoring treatment
-are familiar with the basic cytological tests and their indications, know how to perform these tests and understand the role of different working phases as part of high-quality treatment

Content

Cell components and general characteristics of cell functions; the cell cycle, cell growth, cell differentiation and its regulation; extracellular matrix and cell adhesion and cell death.
Formation, tasks, mobility and functions of blood cells in circulation and other bodily fluids. Factors relating to aspirate sampling and preparation of bone marrow smears. Preparation and staining of blood, urine and aspirate samples for microscopic examination. Recognition and sorting of cells using microscopes and cell counters (staining and cytometry in a chamber and using automated equipment).
Sampling techniques, cytological preparation techniques, basic staining techniques; normal morphology of key cell types and identification of typical cell findings; criteria of malignancy

Prerequisites

Prerequisites:
Anatomy, Physiology and Pathophysiology; Safety culture in health care, Basic Methods in Laboratory Work, Chemistry, Physics and Mathematics

Teaching methods

Interactive lecture, some in Adobe Connect
Guided laboratory assignments
Workshops
Assignments in Moodle
Training in Moodle

Learning materials and recommended literature

BLOOD CELLS:
BioDigi Cell Morphology (Moodle material).
Ruutu, Rajamäki, Lassila, Porkka: Veritaudit, Duodecim 2007 or newer edition (Also in Oppiportti)
Annakaisa Ek: Verisolujen tunnistusaaapinen, Messon 2009
Hoffbrand A.V.; Moss P.A.H. 2011: Essential Haematology. 6th Edition. Wiiley-Blackwell.
Carr J.H., Rodak B.F. 2009: Clinical Hematology Atlas. Third Edition. Saunders Elsevier.
CYTOLOGY:
BioDigi Clinical cytology (Moodle material).
Koivuniemi Ari. (toim.) Kliininen sytologia 1994:
• p.1-98 (Gynekologinen sytologia)
• p.143–166 (Hengityselinten sytologia)
• p. 269-296 (Virtsan sytologia)
p. 345-423 Ohutneulabiopsiat
Dehqanzada Z. 2012. Kuvallinen opetusmateriaali gynekologisen irtosolunäytteen levyepiteelimuutoksista ja muutoksiin vaikuttavista tekijöistä. https://www.theseus.fi/bitstream/handle/10024/51172/NEW%20OK%201.pdf?sequence=1
Saeidpoor R & Seyyed Mansour Ayyoubi: Keuhkon sytologia -oppimateriaali :Normaalit, benignit ja malignisolut bronkusimu- ja harjanäytteissä http://www.theseus.fi/bitstream/handle/10024/51167/Saeidpoor_Roghiyeh.%20Ayyoubi_Seyyed_Mansour.pdf?sequence=1
CELLBIOLOGY AND CELLS IN URINE:
Heino, Vuento: Biokemian ja solubiologian perusteet, Sanoma pro 2014
Moodle
Lection material
Recordings

Alternative completion methods of implementation

N/A

Internship and working life connections

N/A

Exam dates and retake possibilities

Exam 14.10.2020
Re-exams in November and in December 2020

International connections

N/A

Student workload

1 op is 27h for student
Biology of cell 5op
Morfology of cell ( urine partikles) 1op guided laboratory assignment and 0.5op teory
Blood cells: lectures 20 h, guided assignments 24 h, work shops 16 h, independence studies 61 h
Cytology: 4 ECTS
Exam 3 h

Content scheduling

N/A

Further information for students

Guided laboratory assignments are compulsory.
To pass the whole course a student must pass all assignments and the final exam.
Students must confirm their attendance for a course implementation by being present when tuition begins or in another manner agreed with the lecturer; for example, by returning the first course assignment. Students who are unable to attend the first teaching session due to illness may also confirm their attendance by informing the lecturer of this in advance.

Assessment methods and criteria

Workshops
Cell assignments in Moodle
Final exam

Evaluation scale

0-5

Assessment criteria, satisfactory (1)

See a separate framework for evaluation. When evaluating the competences, the evaluation criteria for novice/beginner, competent/intermediate level and expert are used.

Assessment criteria, approved/failed

Approved - fail. See evaluation guide enclosed.