Clinical Biochemistry (15 ECTS)

Learning outcomes

Students
- describe the key metabolic reactions and their regulatory systems and explain the biochemical foundations of laboratory analyses.
- explain the basic functions of the human body and anomalies in disease processes and apply this knowledge in their actions.
- justify the applications of laboratory tests in promoting health, diagnosing diseases and monitoring treatment.
- describe the pre-analytical requirements and clinical significance of the most common clinical biochemistry tests, therapeutic drug assays and toxicology screens and apply these when performing clinical biochemistry tests.
- explain the principles of the methods that they use.
- carry out and assess the most common clinical biochemistry tests, some therapeutic drug assays and toxicology screens.
- explain the operating principles of clinical chemistry analysers and operate and service this equipment. Students assess the reliability of laboratory results and testing processes and apply quality control methods to their own work

Content

Amino acids, proteins, enzymes; fluid and electrolyte balance and its regulation; acid-base balance and its regulation; carbohydrate and lipid metabolism and their regulation; formation of bile pigments and nitrogenous waste products; vitamin and hormone metabolism.
Key clinical biochemistry and pharmacology tests, including special requirements for taking and handling samples, analysis and methodological principles (photometry, potentiometry, amperometry, electrophoresis, chromatography, immunological methods and mass spectrometry), assessment of the reliability of results, clinical significance of results and sources of error for assays. Key tests cover proteins, enzymes, hydrocarbons, lipids, electrolytes, acid-base balance, bile pigments, nitrogenous waste products, as well as therapeutic drug assays, toxicology screens, quality control in clinical biochemistry tests, working with automation and point of care (POC) analysis in clinical biochemistry. Methods validation and development of laboratory work in clinical biochemistry

Prerequisites

Prerequisites:
Anatomy, Physiology and Pathophysiology; Immunology; Pre-analytics;Basics Methods in Laboratory Work, Chemistry, Physics and Mathematics, Cell Biology, Cell Morphology and Cytology

Teaching methods

Independent classies /virtual learning
Contact teaching
Practice

Location and time

Ajanjakso 18.1 - 14.3.21
Opintojakso alkaa 18.1.21 pakollisella orientaatiolla. Läsnäololla varmistetaan paikka opintojaksolla.

Learning materials and recommended literature

Material:
Biochemistry:
Luentomateriaali sekä seuraava lähdekirjallisuus:
Richard Harvey, Denise Ferrier, 2011: Biochemistry (Lippincott´s Illustrated Reviews)
Duodecim. Ravitsemustiede.
David L. Nelson & Michael M. Cox: Lehninger Principles of Biochemistry
Clinical biochemistry:
Niemelä Onni, Pulkki Kari 2010: Laboratoriolääketiede, Kliininen kemia ja hematologia
Moodi 2/2013 ja 6/2014 ja 2/2008
Bishop Michael, Duben-Engelkirk Janet, Fody Edward: Clinical Chemistry
Välimäki Matti, Sane Timo, Dunkel Leo: Endokrinologia
Point of care:
Moodi 3/15 Laatua vieritutkimuksiin. Labquality Oy.
Moodi 3/14 Vieritutkimusten teemanumero. Labquality Oy.
Annetut artikkelit
Biokemiallisten menetelmien fysiikka: Materiaali Moodlessa
Physics of biochemical methods: Material on Moodle.

Alternative completion methods of implementation

N/A

Internship and working life connections

N/A

Exam dates and retake possibilities

exam in biochemistry (theory): xxxx
EXAM: xxxx
Retakes: xxxx
Physics of biochemical methods: An assignment on Moodle. Dead line agreed during the lessons.

International connections

N/A

Student workload

15 credits = 405 hours students works

Content scheduling

Clinical Biochemistry

Further information for students

Tuition in Finnish.
More information on Moodle.

Assessment methods and criteria

Continuous assessment
Learning assignments
Skills demonstration
Peer evaluation
Exams

Evaluation scale

0-5

Assessment criteria, satisfactory (1)

See a separate framework for evaluation. When evaluating the competences, the evaluation criteria for novice/beginner, competent/intermediate level and expert are used.

Assessment criteria, approved/failed

Approved - fail. See evaluation guide enclosed.